List Of Common Genes Of ADHD, Asd ( ASD ) - 780 Words

RESULTS: 1. Results from MalaCards: With the help of GeneCardsSuite, a list of genes was retrieved. For ADHD, 67 genes were reported, 39 for ID, 86 for ASD and out 242 only top 100 closely related genes were taken for SZ (Table.1). Further common genes were isolated for multiple disorders. A list of common genes can be seen in the Table.2. 2. Results from: STRING: An interaction pattern of 10 common genes among ADHD, SZ, ASD, was analyzed (Figure 13). Interactions in STRING are derived from five main sources, which include, genomic Context Predictions, High-throughput Lab Experiments, (Conserved) Co-Expression, Automated Textmining, Previous Knowledge in Databases. Out of the above mentioned sources, only experimentally evident†¦show more content†¦5. Results from Molinspiration: With the help of ‘Canonical SMILES’ of phytochemicals taken from PubChem, virtual screening was performed. All the phytochemicals which followed the Lipinski’s rule of five were shortlisted, as shown in Table.9 6. Target genes: After the careful analyzation of results from STRING and GeneMANIA, SLC6A3 and DRD2 genes were found to be majorly responsible for the cause of Attention Deficit Hyperactivity Disorder, Schizophrenia, and Autism Spectrum Disorder. This could be seen Table.5 7. Target Pathway: â€Å"Dopaminergic synapse† pathway was found to possess the involvement of genes SLC6A3 (Dopamine Activated Transporter) and DRD2 (D2: Dopamine receptor2). Figure.18 displays the pathway shared by the common genes of ADHD, ASD, SZ. 8. Modeled target proteins: With the help of MODELLER 9.18, DAT (Dopamine transporter) and D2 (Dopamine receptor) were modeled. Out of the 5 modeled structures of each, the best were selected on the basis of lowest DOPE score, as shown in Table 6 and 7 respectively. The models were viewed via RasMol shown in figure 19 and 20. 9. Docking result: Target protein Dopamine Activated transporter (SLC6A3) was chosen and 5 best ligands according to the Molinspiration result were selected for docking process with AutoDock vina, MGLTools1.5.6. Figure 21-25 display the interaction between ligand and reseptor via Discovery studio visualizer. It was found that Oroxylin A from theShow MoreRelatedIntroduction. Managing Autism Can Be A Challenge To Cope1397 Words   |  6 PagesIntroduction Managing autism can be a challenge to cope with in any family with-out understanding ASD. In the article, Autism Spectrum Disorder, Catherine Lord explains autism spectrum disorder, or ASD, as a neurodevelopmental syndrome that is defined by deficits in social reciprocity and communication, and by unusual restricted, repetitive disorder (2000. P355). Parenting a child on the autism spectrum is difficult for any parent who is uneducated about the specific disorder their child is facedRead MoreUnderstanding Autism And The Different Disorders On The Autism Spectrum1225 Words   |  5 Pagesdamage. FXS is the most common inherited cause of intellectual disabilities and is strongly linked to the Autism Spectrum Disorder (ASD) on a behavioral and molecular level (Hagerman et al., 2009). The change or mutation on the X chromosome that causes FXS is called the Fragile X Mental Retardation-1 gene or the FMR-1 gene. The FMR-1 gene is found in every cell in the body. The protein that this gene produces is vital to correct human development. With FXS the FMR-1 gene either makes too littleRead MoreAsperger’s Syndrome: Madness, Savantism, or Genius2985 Words   |  12 PagesPsychiatrists’ Academic Psychiatry that the â€Å"genes linked to Asperger’s were the same as those associated with creativity and genius†. However, there is no empirical evidence of this. There are several a few theories, though, of the cause of this disorder, which are presented in the research section of this paper. Asperger’s Syndrome – Characteristics There are many theories and continuing debate about whether or not Asperger’s and other conditions (such as ADHD-Attention Deficit Hyperactivity Disorder)

Henry David Thoreaus Where I lived, and What I Lived For...

Henry David Thoreaus Where I lived, and What I Lived For I found Henry David Thoreau?s ?Where I Lived, and What I Lived For? made a very convincing argument. He has many examples to support his beliefs. Thoreau stresses the importance and value of living the simplest life nature affords, which I believe is as important now as it was in his day. ?Where I Lived, and What I Lived For? opens with Thoreau describing how he came to live in a small, dilapidated cabin near Walden Pond. He speaks of the many farms he imagines owning, yet never does. Thoreau describes the landscape of the pond and the surrounding area. One of the highlights of Thoreau?s simple daily routine is to watch the sun rise and set on the pond. The†¦show more content†¦He says, ?I did not need to go out doors to take the air, for the atmosphere within had lost none of its freshness. It was not so much within doors as behind a door where I sat, even in the rainiest weather? (13). The cabin?s location also attributes to the simplicity Thoreau portrays. I like the great analogy Thoreau uses to express how remote the cabin is. He says that to his neighbors, he must look as a distant star because he is so far away. Thoreau uses straightforward language to express his point. He states directly, ?Simplicity, simplicity, simplicity!? (16). He believes that we should have no more than one or two affairs at a time. Thoreau jokingly writes about man?s need to build a railroad to make our lives simpler. He asks, ?And if railroads are not built, how shall we get to heaven? But if we stay at home and mind our business, who will want railroads (16). Many believe that by building railroads we will simplify traveling, but in truth the work it takes to upkeep the railroads has only further complicated our lives. I love Thoreau?s assertion that if everyone agrees to slow down, our lives would be much simpler. This is true today too, in that a when four-lane highway becomes congested, it is turned into a six or eight lane highway. This, however, rarely eases the congestion. In this way, Thoreau?s assertion remains true. Thoreau then makes a very valid point about theShow MoreRelated Henry Thoreaus Where I Lived and What I Lived For and E.B. Whites Once More to the Lake991 Words   |  4 PagesHenry Thoreaus Where I Lived and What I Lived For and E.B. Whites Once More to the Lake At first glance, Henry Thoreau’s, Where I Lived and What I Lived For, and E.B. White’s, Once More to the Lake, have nothing in common. After several readings; however, one can interpret that both authors have the same message. Even though Thoreau and White use extremely different styles, they both portray nature as the simplest way of life. Thoreau writes an argumentative essay in the 1800’s trying to persuadeRead MoreEssay Biography of Henry David Thoreau1090 Words   |  5 PagesBiography of Henry David Thoreau Henry David Thoreau was born July 12, 1817. He was born in Concord, Massachusetts. He lived a wonderful life as a poet and essayist. Its sad to say that he pasted away on May 6, 1862 in Concord. The first year of his life his family moved away, but also returned five years later. He grew up in a village and later reached his manhood. His favorite thing about the village was the woodlands, streams, and meadows. He was the third child in his family. As his lifeRead MoreChris Mccandless And Henry David Thoreau755 Words   |  4 Pages Both Chris McCandless and Henry David Thoreau explore the idea of authentic living and simplicity, throughout both texts they portray their ideas to the audience. 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He compiled a novel titled Walden, a no n-fiction depicting his stay at Walden Pond where he truly explored nature and his transcendentalRead MoreWalden and Transcendentalism Essay1545 Words   |  7 PagesWALDEN AND TRANSCENDENTALISM Henry Thoreau’s masterpiece, Walden or a Life in the Woods, shows the impact transcendentalism had on Thoreau’s worldview. Transcendentalism is a philosophy that asserts the primacy of the spiritual over the material. Transcendentalism puts the emphasis on spiritual growth and understanding as opposed to worldly pleasures. Thoreau’s idea of transcendentalism stressed the importance of nature and being close to nature. He believed that nature was a metaphorRead MoreHenry David Thoreaus Sociological Experimentation in Isolation655 Words   |  3 PagesIn Henry David Thoreau’s writings, he explores a different, more thoughtful way of life. Thoreau was a student of Ralph Waldo Emerson. Emerson gave Thoreau the property on Walden Pond in Concord, Massachusetts; where Thoreau spent about two years living away from the society. Thoreau’s social experimentation required him to separate himself from the society, to be an individual, and to learn from his experiences. Henry David Thoreau was given a piece of property on Walden Pond by Emerson. EvenRead MoreThoreau And Transcendentalism Analysis828 Words   |  4 PagesThoreau’s views on Transcendentalism and how he practiced it. If it has not become apparent thus far Emerson and Thoreau were close friends and lived with each other on occasion. Naturally because of their close friendship they influence each other’s work, but in most cases you can see Emerson’s influence in Thoreau’s works clearly. His is the main difference between the two writers however in their belief and writing patterns Thoreau loved nature. Thoreau’s love of nature can e explained here inRead MoreEgoitarianism In Henry David Thoreau1662 Words   |  7 Pages As one of the most respected and honored writers in all of American literature, millions have idolized Henry David Thoreau for his transcendental ideologies seen throughout many of his works, such as â€Å"Walden†. However is t his respect deserved? Thoreau critics describe him as a very conceited, hypocritical, and egotistical individual who had little respect or empathy for humanity. On the other hand, those in praise of Thoreau describe his writing as unparalleled in terms of detailed descriptionsRead MoreEssay on Where I Lived and What I Lived for608 Words   |  3 PagesHenry David Thoreaus Where I lived, and What I Lived For I found Henry David Thoreau?s ?Where I Lived, and What I Lived For? made a very convincing argument. He has many examples to support his beliefs. Thoreau stresses the importance and value of living the simplest life nature affords, which I believe is as important now as it was in his day. ?Where I Lived, and What I Lived For? Opens with Thoreau describing how he came to live in a small, dilapidated cabin near Walden Pond. He speaksRead MoreTranscendentalism: Henry David Thoreau Essay1096 Words   |  5 PagesHenry David Thoreau was born on July 12, 1817 in Concord, Massachusetts. Thoreau grew up in poverty; his dad was unsuccessful and had trouble maintaining a steady job. Thoreau followed in his father’s footsteps, ultimately bouncing from job to job, scorned by society for his unconventional way of living and lack of income (Henry David Thoreau, Discovering Biography). Thoreau began to write with the guidance of Ralph Waldo Emerson who became one of the most important influences in his life. Living

Ladies Of Missalonghi Essay Example For Students

Ladies Of Missalonghi Essay The author of the book, The Ladies of Missalonghi, by Colleen McCullough describes to the reader how Missy, an unattractive woman, in a small town differs from Alicia. Missy, the daughter of Drusilla did not really have any self-confidence in herself. She would begin by wondering what she really looked like. The house owned only one mirror, in the bathroom, and it was forbidden to stand and gaze at ones reflection. Thus Missys impressions of herself were hedged with guilt that she might have stayed too long gazing. Oh, she knew she was quite tall, she knew she was far too thin, she knew her hair was straight and dark, that her eyes were black-brown, and her nose sadly out of kilter due to a fall as a child. She knew her mouth drooped down at its left corner and twisted up at its right, but she didnt know how this made her rare smiles fascinating and her normal solemn expression a clown like tragicomedy(Pg.35-36). Missy didnt really pay close attention to what she really looked liked. It didnt matter how women appeared in those days as how it does today. They seem to think that its evil to look at oneself in the mirror, and that its forbidden for a woman to look at her own image. Life had taught her to think of herself as a very homely person, yet something in her refused to believe that entirely, would not be convinced by any amount of logical evidence. So each night she would wonder what she looked like(Pg.36). She knew what she really looked like, but her conscious was telling her different. It was like she had something in her that was really setting her apart from her family and friends. Even in her mid-twenties she was still treated unfairly. Her mother looked down at her and did not appreciate any of the things that she did. Any pip-dreams Drusilla might have harboured about Missys growing up to snatch the ladies of Missalonghi out of penury via a spectacular marriage died before Missy turned then; she was always homely and unprepossessing(Pg. 39). What h er mother pictured Missy to be had been vanished when Missy was about ten. Her mother lost fate in her before she even had a chance to prove her decency. Missy also was living in her own fantasy world. Her mother was against her from reading romance books because it was a sin to know about love. She was shatter inside for she felt she will never experience love, thus this made her even more interested in romance and love. She also grew up into a family where love was evil and bad. She also never felt that intimate passion that she always wanted to feel. Her mother may have made her believe in other things that wasnt true, but she wasnt going to abide by it. Missy felt that she was in-slaved by her mother and her aunts. Her mother made her do all the chores even when she was so sick that she couldnt move out of bed. When she got so sick and fainted, her mother and aunt were worrying about who was going to do the chores. She was like Cinderella who was left behind to clean and do everything. Even when she left the house to go get something, she always thought about milking the cows and that she had to hurry back before her mother would get mad at her. She had such a big responsibility that she didnt have any time for anyone, not even for her self to enjoy. Oh let it not be brown! Prayed Missy. I want a scarlet dress! A lace dress in the sort of red that makes your eyes swim when you look t its thats what I want!?brown, Drusilla finished at last, and sighed(Pg.51). She wanted a brown dress out of all the colors she had to pick from. She always felt that she matched brown best aside from other colors. The color brown which made her figure e ven more darken, is the color that she liked best. I understand how disappointing this must be, but the truth of the matter is, Missy, that no other colour becomes your half so well as brown! In pastels you look sick, in black you look jaundiced, in navy you are at deaths door, and the autumn tones turn you into a Red Indian(Pg.51). Even her own mother did not have any confidence in her. She suggests that she wears a brown dress because it matches her best. She became very upset that her mother thought that brown was the only color she liked. She really liked the pastel dress a lot and was overjoyed. Brown; what an ugly color(pg. 66). She hated the color brown, but she wears it the most. Missy, like a shadow who was never noticed is beginning to come out of the dark. Missy also has a serious heart problem. From time to time she would faint and not even know that she fainted. Her mother didnt really pay much attention to Missy, and her illness. They all had more serious stuff to hand le than her illness. Her mother and her aunt were worrying about who was going to be the next Ladies of Missalonghi and that who was much prettier. She also had a cousin by the name of Alicia Marshall. A truly exquisite creature, Alicia Marshall. Very tall and built on voluptuous yet disciplined lines, she was angelically fair of skin and hair and eyes, with beautiful hands and feet, and a swanlike neck. As always, she was dressed in perfect taste, and wore her ice-blue silk gown (eyelet embroidered, its shorter overskirt fashionably pointed) with incomparable flair and grace(pg.47) Alicia was different from Missy. She wore very nice and elegant clothing and looked very fantastic. She is also the same age as Missy, but with a whole different attitude and posture. Alicia arrived in a motor car, which in those days only the wealthy had motor cars. She also was chauffeured and was treated like a queen. Even though they were both the same age; Alicia had the potential to start her own h at store, unlike Missy who was still at home and being bossed around. It seemed as though Missy had no social life, and that she never knew how the outside world was like. Her mother also treated her like a child as though she had nothing to live for. They seem to think that Alicia has it all, she has the look, the wealth, and the men kissing at her feet. Alicia had an intimate relationship and discovered what love was. She had romance and enjoyed her everyday life. She didnt care about what other people would think because she had her beauty to rely on. Even Missys mother respected Alicia, she lost her dreams and hope for Missy therefore she transferred it towards Alicia. As pretty and smart the town thought Alicia was, she ran off with the chauffeur to get married. As I have described the differences between Missy and Alicia, their roles change. Missy finally finds her romance and love, and the intimacy she always wanted. Her husband, a wealthy man, makes her part of his company a nd Alicia runs off with a chauffeur who makes less than what she made at her hat store. Missy finally leaves home and the torment from her mother and aunts. .u0ec362a1fc1823e5b355bed8230315cc , .u0ec362a1fc1823e5b355bed8230315cc .postImageUrl , .u0ec362a1fc1823e5b355bed8230315cc .centered-text-area { min-height: 80px; position: relative; } .u0ec362a1fc1823e5b355bed8230315cc , .u0ec362a1fc1823e5b355bed8230315cc:hover , .u0ec362a1fc1823e5b355bed8230315cc:visited , .u0ec362a1fc1823e5b355bed8230315cc:active { border:0!important; } .u0ec362a1fc1823e5b355bed8230315cc .clearfix:after { content: ""; display: table; clear: both; } .u0ec362a1fc1823e5b355bed8230315cc { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u0ec362a1fc1823e5b355bed8230315cc:active , .u0ec362a1fc1823e5b355bed8230315cc:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u0ec362a1fc1823e5b355bed8230315cc .centered-text-area { width: 100%; position: relative ; } .u0ec362a1fc1823e5b355bed8230315cc .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u0ec362a1fc1823e5b355bed8230315cc .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u0ec362a1fc1823e5b355bed8230315cc .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u0ec362a1fc1823e5b355bed8230315cc:hover .ctaButton { background-color: #34495E!important; } .u0ec362a1fc1823e5b355bed8230315cc .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u0ec362a1fc1823e5b355bed8230315cc .u0ec362a1fc1823e5b355bed8230315cc-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u0ec362a1fc1823e5b355bed8230315cc:after { content: ""; display: block; clear: both; } READ: A Clockwork Orange EssayBibliographyMcCullough, Colleen. The Ladies of Missalonghi. New York, New York. Avon Books, Inc. 1987

Blood Turns The Wheels Of Our Lives free essay sample

Essay, Research Paper Blood Turns the Wheels of our Lifes Guns have played an of import function in the defining of America, from the revolution in 1776 to the rampant offense of modern twenty-four hours. They have been used to contend two universe wars and halt dictatorship all across the Earth. The ownership and use of guns in America is good because it advocates self defence, supports the conflict against dictatorship, and encourages psychological development in society. Crime in America does non fluctuate in conformity to guns and conceptual ego defence demands to be more fecund and recognized. Crime has ever taken topographic point and will ever take topographic point, and felons will ever hold guns ; this world allows people no pick except to understand and accept the function of guns. The most important gun control Torahs of the 20th century have had small affect on offense and decease rates. The National Firearms Act of 1939 and the Gun Control Act of 1968 had perfectly no evident affect on the invariably fluctuating decease rates ( GunTruths. com ) . In fact the slaying rate rose significantly twelve old ages following the Gun Control Act of 1968 ( GunTruths.com ) . Since 1900 the figure of pieces in the state has invariably risen. However, the figure of violent offenses caused by pieces has been in flux, without any respect to gun ownership. At the terminal of the 20th century the greatest figure of pieces are owned, yet the slaying rate is at a 30 twelvemonth low ( GunTruths.com ) . In a survey by the University of Chicago sing the disincentive of offense because of pistols, it was shown that slaying was reduced by 8.5 per centum, colzas by 5 per centum and aggravated assaults by 7 per centum ( GunTruths.com ) . Guns are an imperative portion of endurance and protection, without them we will be capable to fear and submission deducing from offense and the menace of force. Tyranny has been a menace in America from it # 8217 ; s get downing old ages as a new state to it # 8217 ; s substantiated place as a universe power. When Great Britain ruled over what is now the United States, subjugation and revenue enhancement without representation were common parts of people # 8217 ; s lives. The allowance of guns within colonial society enabled civilians to contend against Britain and to liberate themselves from civil development. They decided that their hereafter was non one of dictatorship and subjugation, but one of freedom and autonomy. Firearms were the most used arm in the American revolution and without the usage of pieces the state in which we reside would non be today ( Zinn, p.76 ) . Throughout the last two centuries guns have been used to protect freedom and people # 8217 ; s manner of life. When the south succeeded from the brotherhood it was guns which were used to contend for their manner of life. When inkinesss were oppressed in the mid 20th century they turned to transporting guns for protection. The Black Panthers carried pieces for their ain protection in the mid 20th century. Today all around the universe the American authorities conflicts against undemocratic and oppressive forces utilizing pieces. The usage of guns against subjugation is a really of import construct for Americans to understand for it could be extremely necessary someday. Americans could be faced with a determination to take up weaponries someday and dice on their pess instead than populate on their articulatio genuss. Fatal gun accidents take topographic point all around our state. Peoples have become sympathetic and weak to this state of affairs, particularly in respects to the deceases of immature kids. There were one-thousand-five 100 inadvertent deceases due to pieces in 1997 ( FBI.gov ) . Merely two-hundred and 20 of those deceases were kids, which is merely approximately 15 per centum of the entire sum ( FBI.gov ) . In many instances these accidents occur because an person has acted irresponsibly with a piece, in decision pickings their ain life. In other instances person will move irresponsibly and take person else # 8217 ; s life. In the first state of affairs the individual deserves to decease for moving with a deficiency of intelligence. Society is better off without these potentially unsafe people. Their station in life could be one taking to the decease or hurts of persons around them. In the 2nd state of affairs the individual # 8217 ; s life is given in order to learn the attacker and society the dangers of intellectually inferior people. These people who by chance shoot another individual should be regarded as inept and exemplified as a failure in society. The decease of their victim is a sufferer # 8217 ; s decease, one that is looked upon as something that benefited society. The accidents that could potentially take topographic point due to pieces are calamities that further the psychological promotion of society. Firearms have affected America in many positive ways in respects to the combat of oppressive forces, supporting one # 8217 ; s self and germinating society psychologically. Gun will ever be an component in our lives ; if they are outlawed, so the lone people who will have guns will be the felons. Firearms have been an optimum tool in America, they guarantee our freedom and they will play a big function in any major struggle in old ages to come. Guns allow us to free ourselves of potentially negative parts of our society, such as irresponsible persons. Everyone can profit from the allowance of guns in our society, for if we don # 8217 ; t protect ourselves and make our ain freedom, who # 8217 ; s traveling to make it for us?